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While these drugs have proven to be safe through their use in millions of individuals with Type 2 diabetes, the newer more-effective drugs as well as their applications in novel diseases will require long-term studies to provide safety data

They: Slow gastric emptying, which can help you feel fuller longer Increase the release of insulin when sugar is present, which can help ward off spikes and crashes in blood sugar levels Suppress glucagon secretion, which in turn reduces liver glucose output Stimulate glucose uptake into cells and increase glucose uptake and storage in muscles so you have energy at the ready Increase proliferation of the beta cells in the pancreas that make insulin, which boosts the availability of blood-sugar-modulating insulin Decrease hunger through multiple pathways in the brain, including a quieting of food noise that can reduce the drive to binge eat or seek emotional comfort in food Taken together, these actions often add up to rapid and significant weight loss

Compared to monotherapies that often lead to dose escalation and tolerance, these co-delivery platforms demonstrate prolonged efficacy at lower doses, reducing adverse effects and improving patient outcomes