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In fact, it is reported (Underwood et al., 2010) that exendin-4 (939) binds strongly (EC 50 5 pM, IC 50 0.76 nM) to wild-type GLP-1R than the native GLP-1 (EC 50 11 pM, IC 50 1 nM)

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Common gastrointestinal side effects of tirzepatide include: Nausea (1224% of patients, varying by indication and dose) Diarrhea (1218% of patients) Vomiting (510% of patients) Constipation (511% of patients) Abdominal pain or discomfort Decreased appetite Dyspepsia (indigestion) These effects are typically most pronounced during the initial weeks of treatment and during dose escalation periods

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