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Warnings and Contraindications A personal or family history of medullary thyroid cancer Gastroparesis Multiple endocrine neoplasia type 2 Type 1 diabetes The Takeaway The FDA has granted accelerated approval for GLP-1 receptor agonist drug semaglutide as a first-line treatment for adults with moderate to severe MASH

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Originally developed for type 2 diabetes, these drugs are a prime example of successful drug repurposing, their unexpected benefits on weight loss and cardiovascular outcomes quickly took center stage, catapulting them into a broader spotlight

Pivotal trials for semaglutide show nausea peaks at days 3 to 7, with 70% of patients reporting improvement or resolution by week 6