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Firstly, metformin has been shown to improve lipid metabolism (He, 2020) and therefore has a favorable effect on body weight (Day et al., 2019

It is often an excellent choice for patients who want a single-mechanism GLP-1 therapy with predictable results and a well-established dosing protocol

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Discuss key efficacy and tolerability data from clinical trials published to date with oral semaglutide

In mice and non-human primates, dual GLP-1R/GCGR (glucagon receptor) agonists have been shown to induce excellent glycemic control and significantly greater weight loss than liraglutide monotherapy, increasing energy expenditure and reducing total energy intake by 6070% [158]