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REIMAGINE 2 was a 68-week efficacy & safety trial investigating once weekly SC CagriSema, a fixed-dose combination of the Amylin receptor agonist, cagrilintide, & GLP-1RA, Semaglutide, compared to Semaglutide & placebo, the study enrolled 2,728 patients with type 2 diabetes inadequately controlled with metformin with or without an SGLT2I

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This review will outline the physiology and pharmacological potential of amylin and GLP-1, respectively, and focus on innovative peptide drug development leading to drugs acting on two or more distinct receptors, such as an amylin and GLP-1 peptide hybrid, potentially producing a more effective treatment strategy to combat the rapidly increasing global obesity.