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Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed pharmacological actions.

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If GLP-1s do what the evidence suggests they will do, this will be one of the clearest demonstrations in modern psychiatry of why we fund preclinical research and why translational pipelines matter

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Novo's Wegovy pill already has over 600,000 prescriptions since it was approved in December, and Foundayo doesn't require fasting which is a major differentiator