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In the United States alone, 38.4 million people (11.6% of the population) have diabetes ( [25] )

Semaglutide targets GLP-1 receptors, while tirzepatide targets GLP-1 and GIP receptors

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The anti-inflammatory mechanisms, including NF-kB suppression, TNF-alpha reduction, and macrophage polarization, are directly relevant to IBD pathology

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This multi-receptor targeting approach has shown enhanced effectiveness in glycaemic regulation and weight loss relative to single-receptor agonists, indicating a viable route for future pharmaceutical development