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Many literatures proved that GLP-1 derivatives performed neuroprotective effects and inhibited neuronal apoptosis ( Figure 1 There are also a type of non-peptide small molecules, which are mainly extracted from herbal medicine, such as Cornus officinalis , Gardenia jasminoides , Rehmannia glutinosa , Lamiophlomis rotata , and Strychnos nuzi ( Even for patients without complications of diabetes, their cognitive functions were still significantly improved (28, 29)

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Ann Intern Med 2020;173:278286 [DOI] [PubMed] [Google Scholar] 108

The WHO in 2005 estimated that at least 400 million adults worldwide (10%) were obese

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