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Long-term trials confirm it can still deliver meaningful and sustainable benefits for many patients
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Background: Obesity is a global health challenge with few pharmacologic options

Although the purpose of the study was not to conduct quantitative analyses, questionnaire data showed a trend towards reduction in PHQ-9, GAD-7 and EDE-Q scores (Table 1), which were clinically significant given that change scores of 5, 4 and 0.57 are considered the minimal clinically important differences in PHQ-9, GAD-7 and total EDE-Q scores respectively [3840]

In our study, we provide a new piece of this puzzle by demonstrating that semaglutide directly impact this critical metabolic pathway
