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If side effects persist or worsen, your PlexusDx provider can adjust your dose or switch you to an alternative formulation (oral semaglutide or a dual-compound option like GLP-Squared) rather than pausing entirely

Cardiovascular, metabolic, and safety outcomes with semaglutide by baseline age: post hoc analysis of SUSTAIN 6 and PIONEER 6

Patients with pre-existing gastrointestinal conditions including gastroparesis, inflammatory bowel disease, or chronic nauseamay experience more severe side effects with GLP-1 receptor agonists and should discuss these concerns thoroughly with their healthcare provider

GLP-1R has been reported to generate signals from the endosomal compartment (Kuna et al ., 2013

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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Bonaca MP, Catarig AM, Houlind K, et al