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This single molecule integrates: -GLP-1 receptor agonism -GIP receptor agonism -Pan-PPAR agonism (lanifibranor: PPAR-, PPAR-, PPAR-) Rationale: -GLP-1/GIP pathways: appetite regulation, glucose lowering -PPAR-: adipose tissue differentiation, systemic insulin sensitivity -PPAR-: fatty acid oxidation, triglyceride reduction -PPAR-: enhanced energy utilization Preclinical data are encouraging, showing greater body-weight reduction, improved glucose control, and metabolic benefits compared with current incretin-based therapies