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Exclusion criteria included: (1) animal-only studies without translational relevance

GLP-1 receptor agonists exert neuroprotective effects primarily by inhibiting microglial activation, the primary effector cells of neuroinflammation, thus reducing the production of proinflammatory cytokines (e.g., TNF- , IL-1) and alleviating inflammatory damage to brain parenchyma

Two weeks later, the blood glucose was measured three times randomly, and the average value was more than 16.7 mmol/L

(Kruisselbrink et al

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It suggested that vehicle lacking nutrition caused ATP production through activating LKB1-AMPK pathway and metformin could enhance the signaling