switch from tirzepatide to retatrutide vs Tirzepatide: Which Weight-Loss Drug Is Better? How Is Retatrutide Compared to

Position it more as inspired by the trend, rather than a literal endorsement

Among non-users, injection aversion remains a meaningful barrier to uptake

Current guidelines from the American Diabetes Association now favor GLP-1 agonists over insulin as the first injectable therapy for most patients with Type 2 diabetes

Glycaemic dysregulation, the loss of insulin-mediated paracrine regulation of glucagon, and decrements in glucose disposal into insulin-resistant skeletal muscle contribute to circulating hyperglycaemia and perpetuate insulin resistance in MASLD [6, 15]

When glucose normalizes, insulin secretion falls, which helps reduce the risk of hypoglycemia

9 Patients with T2DM receive exenatide by subcutaneous injection, and circulating exenatide produces a blood glucose-lowering effect since it directly activates the GLP-1R