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Conclusion and future directions With the growing use of GLP-1 agonist medications (currently estimated at one in eight in the US, and one in five women aged 5064 [62]), the need for a thorough assessment of their side effects is becoming increasingly vital in promoting patient health and well-being

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Highlighting the implication of the effects of GLP-1 in adipose tissue, dopamine D1 and D4 receptor expression was decreased and correlated with GLP-1R expression in adipose tissue from patients with obesity compared to healthy controls, where targeting this pathway may have future clinical relevance [115]

[1] [2] This metabolic pathway is significant because many drug interactions occur when multiple medications compete for the same liver enzymes

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