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If you're thinking about stopping, that's a conversation to have with your clinician about tapering strategy and maintenance planning - not a unilateral decision to make on your own

3 This has led to GLP-1 receptor agonists being licensed to promote weight loss in the setting of obesity

By using lower doses than the standard escalation protocol, patients can stretch their medication supply and reduce monthly expenditure

Semaglutide activates the GLP-1 pathway

However, an unphysiologically large postprandial release of GLP1, for example, after gastric bypass surgery (Korner et al., 2007), might reach the circumventricular organs, and DPP4resistant GLP1 receptor agonists clearly have central actions, though whether this includes action on GLP1 receptors inside the BBB or is limited to direct activation of GLP1 receptors in the circumventricular organs outside the BBB, is less clear (Adams et al., 2018

GI side effects may worsen temporarily during this escalation but usually stabilise within 2 weeks