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The hallmarks of oxidative stress, including malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG), are often elevated in chronic pain animal models, highlighting the pathophysiological significance of oxidative damage [26]

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You dont get a peak to those rewards. In human experiments, scientists have observed that the same neurological pathways are stimulated when people gamble or take cocaineor when their blood sugar levels have been artificially changed to stimulate fasting

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