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Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine , 387(3), 205-216

doi: 10.1016/j.npep.2020.102018

That 3-week reset appears to have established a new, higher baseline that has persisted for 4 months

See important warnings & safety info about these medications.
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The PCDS and ABCD have collaborated to produce guidance to support clinical decision making when GLP-1 RAs are unavailable

Each meal adds to your system's fermentation backlog, creating sustained symptoms rather than discrete episodes
