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They represent a meaningful clinical advantage that makes tirzepatide the more potent option for most people

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Consistent with the protective effect of AMPK, knockout or pharmacological block of the G-protein coupled receptor GPR39 was previously found to promote reflow and cardiac protection after ischaemia 56

The combined effect is a cardiovascular system that has less work to do and potentially fewer threats to manage over time
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Dehydration risk increases when appetite suppression is combined with thyroid hypermetabolism, so careful hydration and electrolyte monitoring strengthens safety throughout treatment
