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4) intervention information (classes of study drugs, doses)

No dose adjustments are recommended for patients with renal impairment
Both liraglutide and exendin-4 decrease the size, weight, and proliferation of pancreatic, breast, prostate, ovarian, intestinal, liver, and colon cancer

As a precautionary measure, it has updated the product warnings for Mounjaro to include further advice for patients using oral contraceptives to switch to a non-oral contraceptive or add a barrier method of contraception for four weeks after first taking the medicine and for four weeks after each increase in the dose

Although many preclinical studies suggest that GLP-1R agonism can act directly on neurons to prevent cell death, this neuroprotective property may be secondary to reduced glucotoxicity and inflammation in the brain that can result from weight loss and improvements in glycemic control (Berkseth et al., Effectiveness of GLP-1R agonists on weight loss in humans Despite not have a complete understanding of the underlying molecular mechanisms, GLP-1R activation clearly has beneficial effects on both energy and glucose metabolism across a number of species

Meanwhile, Eli Lilly has issued a warning about compounded tirzepatide that may contain B12 or other additives
