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Upon food ingestion and its subsequent entry into the small intestine, intestinal L-cells undergo posttranslational processing of the proglucagon gene, leading to the production of glucagon-like peptide-1 (GLP-1), a potent incretin peptide hormone 9

Its just unavoidable

Retatrutide is a triple agonist that adds glucagon receptor activation

Byetta is expected to lose patent protection soon, and a generic injectable exenatide has been filed with the FDA [174]