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Patients with certain genetic variants may respond more strongly to semaglutide monotherapy, while others benefit from dual-pathway activation using tirzepatide or GLP-Squared combinations

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Only 8% of the total cohort were low early responders, and of those, just 23% eventually reached 15% total weight loss

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What was the harm

You want people to be healthy, Santoro says, but are we stressing women out by forcing them to lose weight and to go on a pretty rigorous weight-loss protocol thats actually not helping? GLP-1 drugs may offer a more effective alternative, she says, promoting weight loss with less psychological strain