surmount-1 trial tirzepatide non-diabetic weight loss For the first time, and semaglutide were put in the same trial. SURMOUNT-5. Phase 3b RCT. 751 adults with obesity, no diabetes. 72 weeks. Both drugs at maximum tolerated dose. The With respect to the SURMOUNT-MAINTAIN
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The unit amounts that felt normal for tirzepatide will seem enormous for semaglutide, and vice versa
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Metabolic shifts As patients adjust to the dose, they can tolerate gastrointestinal side effects better and feel more energetic

doi: 10.1056/NEJMoa1901118
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Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al
