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Description
Viking Therapeutics is developing oral formulations of its dual agonist VK2735
Most failed in week 7
Selective DPP4 inhibitors (second generation) were not shown to compromise immune function, as evaluated using in vitro assays of T cell activation
In vivo: In ob/ob mice, administration of Exendin-4 (10 g/kg or 20 g/kg) improved insulin sensitivity and significantly reduced serum glucose and hepatic steatosis
Hyperglycemia may cause vagus nerve dysfunction due to demyelination [38]
As the last step, fibrosis was measured in cardiac segments
