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"Tirzepatide Once Weekly for the Treatment of Obesity." New England Journal of Medicine, 2022, 387(3), 205-216
Increasing awareness about weight management and metabolic health is expanding patient adoption
Randomized, placebo-controlled study of once-weekly exenatide in 44 non-diabetic, obese children ages 1018, which found a 2.3% decrease in BMI with exenatide compared with placebo
Additionally, GLP-1R expression in the nucleus ACBs may also contribute to this satiety function, more directly in the context of food-seeking motivated behaviors and reward signaling [56]
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Nutrients from different foods interact with L-cells in the gut, stimulating higher GLP-1 production
