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New targets: SMAD3 adaptor SPTBN1 Liver-specific knockout of SPTBN1 in mice protects against obesity, providing a potential therapeutic avenue for metabolic disorders (Rao et al

Participants received once-weekly subcutaneous injections of retatrutide at doses of 0.5 mg, 4 mg, 8 mg, or 12 mg, or placebo, over a 24-week treatment period, with gradual dose escalation to the target maintenance dose

Healthcare providers surveyed by the company also reported that facial volume loss is a common concern

Phase II trials for tirzepatide and survodutide, a GLP-1/glucagon receptor co-agonist, have also shown positive outcomes in people living with MASH and obesity, demonstrating reduction of inflammation without worsening of fibrosis (4, 69)