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GIP (glucose-dependent insulinotropic polypeptide) activation enhances insulin secretion and appears to modulate how the body stores and burns fat

Therefore, clinical validation of the effect of adding GLP-1 to metformin treatment in improving beta cell survival and delaying disease progression is warranted

Figure 12) 6 , suggesting that there is a marked difference between diabetic and non-diabetic alpha cells

10.1002/dmrr.3070 45 GlovaciD.FanW.WongN

Serious complications are rare: pancreatitis at 0.3%, gallbladder events at 1.4%, and acute kidney injury at 0.7% (all associated with dehydration)
