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The GI symptom rates nearly doubled when participants skipped the lower starting dose

The specifics differ, and those details matter for both effectiveness and tolerability

However, the evidence is mixed

This reflects a broader access problem that disproportionately affects lupus patients because their indication for these medications (managing corticosteroid-induced weight gain and reducing cardiovascular risk in an autoimmune condition) does not fit neatly into approved indication categories

Food and Drug Administration (FDA) for weight loss as early as the end of the year 1

I also discontinued medications such as Losartan and certain others after experiencing side effects, while focusing on improving recovery conditions and minimizing environmental and physiological triggers that were affecting my health.