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[DOI] [PMC free article] [PubMed] [Google Scholar] 195.Lhteenvuo M., Tiihonen J., Solismaa A., Tanskanen A., Mittendorfer-Rutz E., Taipale H

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Altering the pharmacokinetic profile, even while maintaining the same total weekly dose, could theoretically affect receptor desensitization patterns, immune response to the peptide, or metabolic adaptation in ways that have not been characterized

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This dual mechanism of action makes tirzepatide an effective and promising treatment option for individuals with type 2 diabetes mellitus and obesity (25)