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When the GIP receptor is activated, pancreatic insulin secretion capacity is enhanced, while fat metabolism and insulin sensitivity also improve

Thus, in contrast to SGLT2 inhibitors that have a clear and consistent hemodynamic mode of action, it is unlikely that kidney hemodynamic actions contribute to the renoprotective effects of GLP-1 receptor agonists

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Due to the high concentration of intracellular chloride ions in GnRH neurons, GABA stimulates GnRH neurons through GABAA receptors and promotes the synthesis and release of GnRH from GnRH neurons

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