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LIMITATIONS OF REVIEW Several limitations characterise the current literature on the psychiatric effects of GLP1RAs

Lean Mass Preservation: The Non-Negotiable Preserve Phase Lean mass preservation is essential during midlife GLP-1 therapy because estrogen decline already accelerates muscle loss

This local gut distribution of GLP-1 receptors supports a potential bidirectional interaction between GLP-1 signaling and the gut microbiota, which could potentially contribute to the therapeutic benefits observed

Liquid-based meals are easier to digest, more hydrating, and less likely to trigger nausea than solid foods

Patients who continue eating adequate protein, exercising regularly, and managing stress while using compounded semaglutide report better satisfaction, faster results, and easier long-term weight maintenance than those relying solely on medication without lifestyle support

Db/m mice were set as the Control group, and db/db mice were randomly divided into Model group, Low group and High group