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The proposed mechanisms include GLP-1 mediated changes in blood pressure regulation, effects on retinal and optic nerve blood flow, and potential interactions with cardiovascular risk factors that are common in the populations taking these drugs

It has GRAS status as a food additive since 2012

This can make it easier to manage appetite and maintain weight loss once GLP-1 treatment ends

Acta Pharm Sin B 12(11):40404055

This exclusivity allows companies to recoup their research and development (R&D) investments and generate profit

De Leon et al compared genes induced by exendin to those expressed following partial pancreatectomy and found a set that included multiple Reg genes as well as fragilis and serpin b1a (21)