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Why Weight Regain Occurs : Biological adaptations that promoted weight gain initially remain present Appetite and food preoccupation often return when medication stopped Metabolic rate may decrease during weight loss (adaptive thermogenesis) Hormonal changes that defend against weight loss persist Long-Term Management : Most individuals require ongoing medication for sustained weight loss maintenance This is similar to other chronic disease treatments (e.g., blood pressure medications) Obesity is a chronic disease requiring long-term management Strong lifestyle habits help minimize regain but may not prevent it entirely Discuss any plans to discontinue medication with healthcare provider to develop appropriate tapering plan and maintenance strategies

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A registered dietitian or your TrimRx clinician can build a structured meal plan if you find calorie intake dropping below safe levels

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Bottom line: SURMOUNT-1 (Jastreboff 2022 NEJM) showed 20.9% weight loss with tirzepatide at 72 weeks FAQ Can I Get a GLP-1 Prescription in West Virginia Without an In-person Visit

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