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This deprives other organs, such as the brain and lungs, of blood flow, which can lead to organ damage and potentially organ failure

In the DURATION-6 trial, the clinical efficacy of once-weekly exenatide was evaluated and compared to that of liraglutide, an FDA-approved GLP-1R agonist79)

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Gut 48 , 548557 (2001)

Overall, preclinical and phase 1 data support that the primary mechanism for weight reduction by tirzepatide is regulation of appetite and decreases in food cravings and food intake, with increased lipid metabolism [76]