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Additionally, it was recently reported that GLP-1RA can also promote cell growth, survival, proliferation and regeneration (47) and inhibit cell apoptosis ( 3 Clinical mechanism and application of GLP-1RA 3.1 Mechanism of GLP-1RA The molecular mechanism of GLP-1RA is intricate ( Figure 1 )

GLP-1 receptor agonists are not recommended in patients with a family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2A or 2B, due to an association between GLP-1 receptor agonists and benign and malignant thyroid C cell tumors in rodents [49]

However, in our experimental model with BRIN-BD11 cells, 18 h exposure to 50 nM Ex-4 did not induce significant changes in cell numbers (Fig
