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Completion of the trials main phase is expected in September 2025, and the 52-week extension (in which participants and investigators remain blinded to treatment assignment) will continue to October 2026

The retatrutide dosage chart shows the titration schedule that produced these results, and understanding the complete dosing schedule is essential for anyone tracking this medication through clinical development

But GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound safely and effectively decrease appetite and improve blood sugar levels

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Finally, individuals with a history of heart failure, ischaemic heart disease, unstable angina, myocardial infarction, aortic aneurysm or dissection, stroke (ischaemic or haemorrhagic stroke), cerebral infarction, transient ischaemic attack, carotid intervention or surgery, coronary stenting, percutaneous coronary intervention (PCI) or coronary artery bypass before inclusion to the cohort or prior to the index event were also excluded