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Description
LP1 is both anxiogenic and antidepressant

In the brain, preproglucagon expressing neurons are localized to the brainstem in regions including the nucleus of the solitary tract (NTS) and ventrolateral medulla (Merchenthaler et al., 1999) and these neurons produce a number of peptides including GLP-1, oxyntomodulin, and glucagon-like peptide-2 (Holst, 2007)

In murine and human islets, GLP-1, via phospholipase C (PLC), leads to an activation of PKC, followed by membrane depolarization and stimulation of insulin secretion

Loureno et al

Katole, N

2009;297:F1647F1655
