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DPP-4 inhibitors (such as sitagliptin, linagliptin, or saxagliptin) enhance the body's own incretin system and are sulfonamide-free oral medications with a low risk of hypoglycaemia

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They aid weight loss by mimicking the glucagon-like peptide-1 (GLP-1) hormone, which regulates blood sugar levels and blunts appetite

This is analogous to respirophasic septal shift and changes in mitral and tricuspid inflow velocities seen on echocardiogram

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