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Specifically, the presence of GLP1 or analogs exerts significant depolarization making them more excitable [96] in hypothalamic neurons, including an increment in the firing rate in gonadotropin-releasing neurons (GnRH) at the hypothalamus [97]

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The move from injectables to solid oral dose reflects a broader shift toward medicines that are easier to use, easier to scale and better suited to long-term patient needs