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This dual mechanism allows Mounjaro to potentially offer stronger effects on both insulin control and appetite regulation
(13), and others likely reflect differences in experimental paradigms, including the specific GLP-1R agonist used (short acting versus long acting, small molecule versus large molecule, etc.), the route of administration (i.p., s.c., or i.v.), dose, species studied, acute versus chronic analysis, and intrinsic shortcomings in the specific model systems used, such as lack of complete tissue specificity with Cre drivers, incomplete knockdowns, and potential developmental compensation when using constitutively active versus tamoxifen-inducible Cre systems

As for efinopegdutide, a 10 mg dosage demonstrated stronger reduction in LFC compared to SEMA 1 mg, despite a relatively higher safety risk

Cardiovascular effects Heart rate increased by 5 to 10 beats per minute across the higher dose groups, peaking around week 24

Large outcome trials like SUSTAIN-6 [15] and EXSCEL [19] reported no significant reductions in HF-related hospitalizations

I started at 1mg and increased gradually over weeks
