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Cotter DG, Schugar RC, Crawford PA
Del Prato S, Kang J, Trautmann ME, Stewart J, Sorli CH, Derwahl M, et al
In a recent study in SH-SY5Y cells treated with 6-OHDA, both semaglutide and liraglutide protected against 6-OHDA cytotoxicity by increasing autophagy flux and decreasing oxidative stress as well as mitochondrial dysfunction, with semaglutide being superior compared to liraglutide [90]
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Key Effects: Kidney-Focused Regulation Acts on renal proximal tubules independently of insulin
Are other dual-agonists in development as effective, and what factors (e.g., tolerability profile) may allow for competitive differentiation
