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As compared with nonobese HFpEF, patients with obesity-related HFpEF display distinct pathophysiologic features, including greater volume expansion 5,17 , more severe inflammation 6,7 , increases in visceral and paracardiac adipose tissue 5,15,18,19 and more severe myocardial injury 15
The primary concern is additive nausea, as both medications list nausea as a common side effect
For patients with comprehensive coverage, the $145/month membership plus a low co-pay could be the most affordable path to brand-name Wegovy or Zepbound
The other big difference outside of effectiveness is that liraglutide medications are injected daily
L-carnitine theoretical contribution to muscle preservation is indirect
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