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The Core GLP-1 Mechanism GLP-1 Pathway Simplified Meal Intake Intestinal L-cells release GLP-1 GLP-1 binds GLP-1 receptors cAMP signaling Activation of PKA + PI3K/Akt pathways Multiple metabolic benefits Practical Clinical Effects In the Pancreas Insulin secretion from -cells Glucagon secretion from -cells Preservation of -cell mass Reduced -cell apoptosis In the Brain Appetite suppression Satiety enhancement Reduced food cravings In the Gastrointestinal Tract Delayed gastric emptying Reduced postprandial glucose spikes In Peripheral Tissues Improved glucose uptake Enhanced insulin sensitivity Reduced hepatic gluconeogenesis Evolution of GLP-1 Therapy: Historical Milestones Current Era Emergence of: Oral GLP-1 drugs Dual agonists Triple agonists Small-molecule GLP-1 therapies Current GLP-1 Agents Short-Acting Exenatide Lixisenatide Long Acting Liraglutide Dulaglutide Semaglutide Oral GLP-1 Oral semaglutide Orforglipron (new generation oral small-molecule GLP-1RA) Dual Agonists Tirzepatide (GLP-1 + GIP) Triple Agonists Retatrutide (GLP-1 + GIP + glucagon receptor) These newer agents are redefining obesity medicine and cardiometabolic care

Journal of clinical hypertension (Greenwich, Conn) 2016;18(6):51421

R.ForrerF.BrandleM.et al (2011)

Patent Information: 2026 Novo Nordisk (semaglutide) Tablets 1.5 mg Rx only DISPENSE WITH MEDICATION GUIDE Note to Pharmacist: Individual strengths of semaglutide are not substitutable on a mg-to-mg basis New Formulation of semaglutide 30 tablets (semaglutide) Tablets 4 mg Rx only DISPENSE WITH MEDICATION GUIDE Note to Pharmacist: Individual strengths of semaglutide are not substitutable on a mg-to-mg basis New Formulation of semaglutide 30 tablets (semaglutide) Tablets 9 mg Rx only DISPENSE WITH MEDICATION GUIDE Note to Pharmacist: Individual strengths of semaglutide are not substitutable on a mg-to-mg basis New Formulation of semaglutide 30 tablets (semaglutide) Tablets 3 mg Once daily Oral use only Rx only DISPENSE WITH MEDICATION GUIDE 30 tablets (semaglutide) Tablets 7 mg Once daily Oral use only Rx only DISPENSE WITH MEDICATION GUIDE 30 tablets (semaglutide) Tablets 14 mg Once daily Oral use only Rx only DISPENSE WITH MEDICATION GUIDE 30 tablets (semaglutide) Tablets 3 mg Once daily Each tablet contains 3 mg semaglutide Oral use only Rx only Dispense the Enclosed Medication Guide to Each Patient 30 tablets 3 blister packs

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