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Downstream signaling from hypothalamic AgRP/NPY/GABA-secreting neurons is considered redundant, meaning that selective stimulation of individual downstream projection areas is sufficient to suppress appetite

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Tirzepatide (Zepbound) - FDA Approved 2023: According to clinical trials cited by multiple sources including NBC News, tirzepatide (a GIP/GLP-1 dual agonist) showed approximately 21% to 22.5% mean weight loss on its highest dose after 72 weeks, compared to approximately 3% for placebo

This has previously led to an issue with HIV medications, where, concerned about the potential for selection, all insurers offering plans in certain rating areas placed all HIV medications in the highest formulary tier