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This gradual approach allows your body to adapt to GLP-1/GIP activation and identifies your optimal tolerability threshold before reaching higher doses

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Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not take these medications

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Orforglipron will likely be available within 12-18 months with no food or water restrictions

Even at the lowest maintenance dose of 5 mg, approximately 85% of participants lost at least 5% of their body weight