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Gut hormone co-agonists for the treatment of obesity: from bench to bedside

Metabolism , 161 , 156057.

After achieving target weight on standard doses, stepping down to a microdose for long-term maintenance avoids both the cost and side effects of full therapeutic dosing while potentially preventing the regain that occurs with complete cessation

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For weight management medications, NICE guidance specifies different stopping rulesfor example, Wegovy treatment should be reviewed after 6 months, and Saxenda should be discontinued if less than 5% weight loss is achieved after 12 weeks at the maintenance dose