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Competitive Landscape Novo Nordisk has a short-term monopoly on the oral obesity treatment market, however this industry is changing quickly

GLP-1RAs: Beyond glycemic control GLP-1RAs such as semaglutide and the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1RAs tirzepatide enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite through central pathways

Interestingly autoantibody (GAD 65) prevalence in both type 1(40%) and type 2 (25%) diabetes did not predict the severity of gastroparesis [33]

According to a study in mice, semaglutide treatment may stimulate FGF21 in mouse liver and improve FGF21 sensitivity, suggesting an important role of the GLP-1/FGF21 axis in mediating beneficial effects in obesity [90]

Metabolic bariatric surgery across the IFSO chapters: key insights on the baseline patient demographics, procedure types, and mortality from the eighth IFSO global registry report

If you have an eye condition, it doesnt mean you cant take GLP-1 agonists, but it does mean that regular eye check-ups are especially important since these medications may increase the risk of NAION in some people. Your eye doctor may recommend closer follow-up to keep your vision safe