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Importantly, SGLT2i have been shown to enhance heart functional capacity, as indicated by improvements in peak VO2 and performance in the 6-minute walking test (6MWT), both key metrics that reflect overall cardiovascular and metabolic health of patients

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While coronary microvascular dysfunction is linked to worse outcomes in INOCA, its prognostic impact in MINOCA is less clear

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Accessed August 11, 2025.

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