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Hormonal changes particularly declining oestrogen can affect where fat is stored, how the body regulates appetite and insulin sensitivity, and how easily muscle mass is maintained

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Verma S, Poulter NR, Bhatt DL, Bain SC, Buse JB, Leiter LA, Nauck MA, Pratley RE, Zinman B, rsted DD, Monk Fries T, Rasmussen S, Marso SP

The responder rates are more decision-useful than the mean: Tirzepatide roughly doubled the odds of hitting the 25% threshold and nearly tripled them at 30%

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