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In the present investigation, MTX challenge induced ER stress and UPR mainly through the PERK/CHOP pathway, consistent with previous studies on MTX-induced hepatic injury (Schmidt et al., 2022), nephrotoxicity (Song et al., 2021), and cognitive impairment (Lv et al., 2020)

doi: 10.1111/jnc.15969 119 MoscatJDiaz-MecoMT

Taking into consideration the success of oral tolerance induction in mouse models using the plant-based approach, efforts have been made to scale up production and enable commercialization of this production process

Prineas JW, Connell F

R.TaghizadehM.Daneshvar KakhakiR.KouchakiE.BahmaniF.BorzabadiS.et al

Stress Management : Chronic stress can deplete glutathione levels, so practices such as meditation, yoga, or deep-breathing exercises can be beneficial