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The central nucleus of the amygdala plays a crucial role in mediating hypophagia, which is caused by GLP-1 and GLP-1RAs

Gradual tapering over 48 weeks significantly reduces this rebound by allowing hunger hormones to normalize progressively rather than spiking suddenly

The regulatory gray zone that sustained much of the compounding industry through 2023 and 2024 has narrowed substantially, and the FDA is actively working to close it

However, this process will take time

The evolving landscape of obesity pharmacotherapy Nature Reviews Drug Discovery, 2026 1 Obesity pharmacotherapy has moved from weight loss drugs to cardiometabolic disease-modifying therapy Obesity is now framed as a chronic, relapsing, neuroendocrine-metabolic disease, not simply a lifestyle failure
